Both of these types of bubbly are Italian sparkling wines.Moscato d'Asti is only made from the Moscato Bianco grape.Prosecco is made from the Glera grape, but can have other grapes in the blend.
Moscato d'Asti is produced using the Asti method. A single fermentation occurs and is stopped mid-way.Prosecco is made using the tank method. A secondary fermentation occurs in a sealed tank.